Read the paper at https://link.springer.com/article/10.1007/s10654-021-00726-8
Are Mendelian randomization investigations immune from bias due to reverse causation?
It has also often been stated that the fixed nature of the genetic code provides complete immunity to bias from reverse causation in Mendelian randomization studies because genetic variants must precede the outcome in time. Here, we demonstrate how reverse causation can lead to bias in Mendelian randomization analyses.
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