MISS is a population based cohort of women aged 25-65 at start 1990. All women have their geographic origin in the Southern Health Care Region and are of Swedish ethnicity. The participation rate in 1990 was 75% (n=29,600).
The women have been interviewed every ten years with regard to life style-, reproductive-, hormonal-, constitutional- and genetic factors.
Saliva DNA is available for 17,000 of the women in the cohort.
Cohort matched to cancer registry, cause of death registry, out and inpatient registry, drug prescription registry, birth registry, socioeconomic registry, genetic registries and multigeneration registry- Cohort part of the Swedish National cohort initiative (J Sundström).
- Cambridge (BCAC-breast, OCAC-ovary, endometrial Cancer)
- Leeds (melanoma, GenoMel)
- Oxford (breast, ovary and endometrium)
Projects on-going except for cancer include, diabetes, autoimmune disease, physical activity, sun exposure, thyroid disease, and subarachnoid hemorrages. The research group plans to follow the cohort for a whole life time and study the next generation in relation to the index cases. Also, calculate risk factor models for incidence and mortality, follow exposure trends and study cancer prevention.
Håkan Olsson (hakan.olssonm @ med.lu.se)